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A novel design for randomized immuno-oncology clinical trials with potentially delayed treatment effects
The semi-parametric proportional hazards model is widely adopted in randomized clinical trials with time-to-event outcomes, and the log-rank test is frequently used to detect a potential treatment effect. Immuno-oncology therapies pose unique challenges to the design of a trial as the treatment effe...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935831/ https://www.ncbi.nlm.nih.gov/pubmed/29736436 http://dx.doi.org/10.1016/j.conctc.2015.08.003 |