Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs

BACKGROUND: Intrinsic chemoresistance of glioblastoma (GBM) is frequently owed to activation of the PI3K and MEK/ERK pathways. These signaling cascades are tightly interconnected however the quantitative contribution of both to intrinsic resistance is still not clear. Here, we aimed at determining t...

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Detalles Bibliográficos
Autores principales: Haas, Bodo, Klinger, Veronika, Keksel, Christina, Bonigut, Verena, Kiefer, Daniela, Caspers, Julia, Walther, Julia, Wos-Maganga, Maria, Weickhardt, Sandra, Röhn, Gabriele, Timmer, Marco, Frötschl, Roland, Eckstein, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935937/
https://www.ncbi.nlm.nih.gov/pubmed/29755294
http://dx.doi.org/10.1186/s12935-018-0565-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935937/
https://www.ncbi.nlm.nih.gov/pubmed/29755294
http://dx.doi.org/10.1186/s12935-018-0565-4

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