Functional domains of the FSHD-associated DUX4 protein

Aberrant expression of the full-length isoform of DUX4 (DUX4-FL) appears to underlie pathogenesis in facioscapulohumeral muscular dystrophy (FSHD). DUX4-FL is a transcription factor and ectopic expression of DUX4-FL is toxic to most cells. Previous studies showed that DUX4-FL-induced pathology requi...

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Detalles Bibliográficos
Autores principales: Mitsuhashi, Hiroaki, Ishimaru, Satoshi, Homma, Sachiko, Yu, Bryant, Honma, Yuki, Beermann, Mary Lou, Miller, Jeffrey Boone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936065/
https://www.ncbi.nlm.nih.gov/pubmed/29618456
http://dx.doi.org/10.1242/bio.033977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936065/
https://www.ncbi.nlm.nih.gov/pubmed/29618456
http://dx.doi.org/10.1242/bio.033977

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