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Systematic comparison of the statistical operating characteristics of various Phase I oncology designs

Dose finding Phase I oncology designs can be broadly categorized as rule based, such as the 3 + 3 and the accelerated titration designs, or model based, such as the CRM and Eff-Tox designs. This paper systematically reviews and compares through simulations several statistical operating characteristi...

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Detalles Bibliográficos
Autores principales: Ananthakrishnan, Revathi, Green, Stephanie, Chang, Mark, Doros, Gheorghe, Massaro, Joseph, LaValley, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936704/
https://www.ncbi.nlm.nih.gov/pubmed/29740620
http://dx.doi.org/10.1016/j.conctc.2016.11.006