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Systematic comparison of the statistical operating characteristics of various Phase I oncology designs
Dose finding Phase I oncology designs can be broadly categorized as rule based, such as the 3 + 3 and the accelerated titration designs, or model based, such as the CRM and Eff-Tox designs. This paper systematically reviews and compares through simulations several statistical operating characteristi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936704/ https://www.ncbi.nlm.nih.gov/pubmed/29740620 http://dx.doi.org/10.1016/j.conctc.2016.11.006 |