Cargando…
CK2 Phosphorylating I(2)(PP2A)/SET Mediates Tau Pathology and Cognitive Impairment
Casein kinase 2 (CK2) is highly activated in Alzheimer disease (AD) and is associated with neurofibrillary tangles formation. Phosphorylated SET, a potent PP2A inhibitor, mediates tau hyperphosphorylation in AD. However, whether CK2 phosphorylates SET and regulates tau pathological phosphorylation i...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936753/ https://www.ncbi.nlm.nih.gov/pubmed/29760653 http://dx.doi.org/10.3389/fnmol.2018.00146 |