Combining Polygenic Hazard Score With Volumetric MRI and Cognitive Measures Improves Prediction of Progression From Mild Cognitive Impairment to Alzheimer's Disease

Improved prediction of progression to Alzheimer's Disease (AD) among older individuals with mild cognitive impairment (MCI) is of high clinical and societal importance. We recently developed a polygenic hazard score (PHS) that predicted age of AD onset above and beyond APOE. Here, we used data...

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Detalles Bibliográficos
Autores principales: Kauppi, Karolina, Fan, Chun Chieh, McEvoy, Linda K., Holland, Dominic, Tan, Chin Hong, Chen, Chi-Hua, Andreassen, Ole A., Desikan, Rahul S., Dale, Anders M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937163/
https://www.ncbi.nlm.nih.gov/pubmed/29760643
http://dx.doi.org/10.3389/fnins.2018.00260

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