Pinocembrin Protects Blood-Brain Barrier Function and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in a Rat Thromboembolic Stroke Model

Tissue-type plasminogen activator (t-PA) remains the only approved therapy for acute ischemic stroke but has a restrictive treatment time window of 4.5 hr. Prolonged ischemia causes blood-brain barrier (BBB) damage and increases the incidence of hemorrhagic transformation (HT) secondary to reperfusi...

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Detalles Bibliográficos
Autores principales: Ma, YinZhong, Li, Li, Kong, LingLei, Zhu, ZhiMei, Zhang, Wen, Song, JunKe, Chang, Junlei, Du, GuanHua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937499/
https://www.ncbi.nlm.nih.gov/pubmed/29850586
http://dx.doi.org/10.1155/2018/8943210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937499/
https://www.ncbi.nlm.nih.gov/pubmed/29850586
http://dx.doi.org/10.1155/2018/8943210

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