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Mechanistic Insights into the Differential Catalysis by RheB and Its Mutants: Y35A and Y35A-D65A

[Image: see text] RheB GTPase is a Ras-related molecular switch, which regulates the mTOR signaling pathway by cycling between the active [guanosine triphosphate (GTP)] state and inactive [guanine diphosphate (GDP)] state. Impairment of GTPase activity because of mutations in several small GTPases i...

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Detalles Bibliográficos
Autores principales:	Kotyada, Chaithanya, Maulik, Aditi, Srivastava, Anand, Singh, Mahavir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937686/ https://www.ncbi.nlm.nih.gov/pubmed/29750207 http://dx.doi.org/10.1021/acsomega.7b01025

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