RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1

RIT1 belongs to the RAS family of small GTPases. Germline and somatic RIT1 mutations have been identified in Noonan syndrome (NS) and cancer, respectively. By using heterologous expression systems and purified recombinant proteins, we identified the p21-activated kinase 1 (PAK1) as novel direct effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Meyer zum Büschenfelde, Uta, Brandenstein, Laura Isabel, von Elsner, Leonie, Flato, Kristina, Holling, Tess, Zenker, Martin, Rosenberger, Georg, Kutsche, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937737/
https://www.ncbi.nlm.nih.gov/pubmed/29734338
http://dx.doi.org/10.1371/journal.pgen.1007370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937737/
https://www.ncbi.nlm.nih.gov/pubmed/29734338
http://dx.doi.org/10.1371/journal.pgen.1007370

Ejemplares similares