Glutathione disulfide sensitizes hepatocytes to TNFα-mediated cytotoxicity via IKK-β S-glutathionylation: a potential mechanism underlying non-alcoholic fatty liver disease

Oxidative stress and TNFα are critically involved in the initiation and progression of non-alcoholic fatty liver disease (NAFLD). In this study, we investigated the effects of dysregulated glutathione homeostasis, a principal feature of oxidative stress, on TNFα-induced hepatotoxicity and its mechan...

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Detalles Bibliográficos
Autores principales: Dou, Xiaobing, Li, Songtao, Hu, Linfeng, Ding, Lei, Ma, Yue, Ma, Wang, Chai, Hui, Song, Zhenyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938004/
https://www.ncbi.nlm.nih.gov/pubmed/29622764
http://dx.doi.org/10.1038/s12276-017-0013-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938004/
https://www.ncbi.nlm.nih.gov/pubmed/29622764
http://dx.doi.org/10.1038/s12276-017-0013-x

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