Dicer1 downregulation by multiple myeloma cells promotes the senescence and tumor-supporting capacity and decreases the differentiation potential of mesenchymal stem cells

Bone marrow mesenchymal stem cells (BMMSCs) facilitate the growth of multiple myeloma (MM) cells, but the underlying mechanisms remain unclear. This study demonstrates that the senescence of MM-MSCs significantly increased, as evidenced by a decrease in proliferation and increase in the number of ce...

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Detalles Bibliográficos
Autores principales: Guo, Juan, Zhao, Youshan, Fei, Chengming, Zhao, Sida, Zheng, Qingqing, Su, Jiying, Wu, Dong, Li, Xiao, Chang, Chunkang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938708/
https://www.ncbi.nlm.nih.gov/pubmed/29724992
http://dx.doi.org/10.1038/s41419-018-0545-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938708/
https://www.ncbi.nlm.nih.gov/pubmed/29724992
http://dx.doi.org/10.1038/s41419-018-0545-6

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