Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway

Iron overload (IO) has been reported to contribute to mesenchymal stromal cell (MSC) damage, but the precise mechanism has yet to be clearly elucidated. In this study, we found that IO increased cell apoptosis and lowered cell viability in MSCs, accompanied by extensive mitochondrial fragmentation a...

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Detalles Bibliográficos
Autores principales: Zheng, Qingqing, Zhao, Youshan, Guo, Juan, Zhao, Sida, Fei, Chengming, Xiao, Chao, Wu, Dong, Wu, Lingyun, Li, Xiao, Chang, Chunkang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938711/
https://www.ncbi.nlm.nih.gov/pubmed/29725013
http://dx.doi.org/10.1038/s41419-018-0552-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938711/
https://www.ncbi.nlm.nih.gov/pubmed/29725013
http://dx.doi.org/10.1038/s41419-018-0552-7

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