DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity

An individual malignant tumor is composed of a heterogeneous collection of single cells with distinct molecular and phenotypic features, a phenomenon termed intratumoral heterogeneity. Intratumoral heterogeneity poses challenges for cancer treatment, motivating the need for combination therapies. Si...

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Detalles Bibliográficos
Autores principales: Anchang, Benedict, Davis, Kara L., Fienberg, Harris G., Williamson, Brian D., Bendall, Sean C., Karacosta, Loukia G., Tibshirani, Robert, Nolan, Garry P., Plevritis, Sylvia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939057/
https://www.ncbi.nlm.nih.gov/pubmed/29654148
http://dx.doi.org/10.1073/pnas.1711365115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939057/
https://www.ncbi.nlm.nih.gov/pubmed/29654148
http://dx.doi.org/10.1073/pnas.1711365115

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