Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers

ATRX (alpha thalassemia/mental retardation X-linked) complexes with DAXX to deposit histone variant H3.3 into repetitive heterochromatin. Recent genome sequencing studies in cancers have revealed mutations in ATRX and their association with ALT (alternative lengthening of telomeres) activation. Here...

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Detalles Bibliográficos
Autores principales: Udugama, Maheshi, Sanij, Elaine, Voon, Hsiao P. J., Son, Jinbae, Hii, Linda, Henson, Jeremy D., Chan, F. Lyn, Chang, Fiona T. M., Liu, Yumei, Pearson, Richard B., Kalitsis, Paul, Mann, Jeffrey R., Collas, Philippe, Hannan, Ross D., Wong, Lee H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939086/
https://www.ncbi.nlm.nih.gov/pubmed/29669917
http://dx.doi.org/10.1073/pnas.1720391115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939086/
https://www.ncbi.nlm.nih.gov/pubmed/29669917
http://dx.doi.org/10.1073/pnas.1720391115

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