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Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species
Bacterial genomes encode numerous cryptic biosynthetic gene clusters (BGCs) that represent a largely untapped source of drugs or pesticides. Mining of the cryptic products is limited by the unavailability of streamlined genetic tools in native producers. Precise genome engineering using bacteriophag...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939090/ https://www.ncbi.nlm.nih.gov/pubmed/29666226 http://dx.doi.org/10.1073/pnas.1720941115 |