O(6)-methylguanine–induced transcriptional mutagenesis reduces p53 tumor-suppressor function

Altered protein function due to mutagenesis plays an important role in disease development. This is perhaps most evident in tumorigenesis and the associated loss or gain of function of tumor-suppressor genes and oncogenes. The extent to which lesion-induced transcriptional mutagenesis (TM) influence...

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Detalles Bibliográficos
Autores principales: Ezerskyte, Monika, Paredes, João A., Malvezzi, Stefano, Burns, John A., Margison, Geoffrey P., Olsson, Magnus, Scicchitano, David A., Dreij, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939098/
https://www.ncbi.nlm.nih.gov/pubmed/29666243
http://dx.doi.org/10.1073/pnas.1721764115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939098/
https://www.ncbi.nlm.nih.gov/pubmed/29666243
http://dx.doi.org/10.1073/pnas.1721764115

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