Shared epitope–aryl hydrocarbon receptor crosstalk underlies the mechanism of gene–environment interaction in autoimmune arthritis

The susceptibility to autoimmune diseases is affected by genetic and environmental factors. In rheumatoid arthritis (RA), the shared epitope (SE), a five-amino acid sequence motif encoded by RA-associated HLA-DRB1 alleles, is the single most significant genetic risk factor. The risk conferred by the...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Jiaqi, Nogueira, Sarah V., van Drongelen, Vincent, Coit, Patrick, Ling, Song, Rosloniec, Edward F., Sawalha, Amr H., Holoshitz, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939100/
https://www.ncbi.nlm.nih.gov/pubmed/29666259
http://dx.doi.org/10.1073/pnas.1722124115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939100/
https://www.ncbi.nlm.nih.gov/pubmed/29666259
http://dx.doi.org/10.1073/pnas.1722124115

Ejemplares similares