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Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor

Lysosomes have an important role in cellular protein and organelle quality control, metabolism, and signaling. On the surface of lysosomes, the PIKfyve/Fab1 complex generates phosphatidylinositol 3,5-bisphosphate, PI-3,5-P(2), which is critical for lysosomal membrane homeostasis during acute osmotic...

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Detalles Bibliográficos
Autores principales:	Malia, PC, Numrich, Johannes, Nishimura, Taki, González Montoro, Ayelén, Stefan, Christopher J., Ungermann, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939101/ https://www.ncbi.nlm.nih.gov/pubmed/29674454 http://dx.doi.org/10.1073/pnas.1722517115

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