The evolution of CpG density and lifespan in conserved primate and mammalian promoters

Gene promoters are evolutionarily conserved across holozoans and enriched in CpG sites, the target for DNA methylation. As animals age, the epigenetic pattern of DNA methylation degrades, with highly methylated CpG sites gradually becoming demethylated while CpG islands increase in methylation. Acro...

Descripción completa

Detalles Bibliográficos
Autores principales: McLain, Adam T., Faulk, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940106/
https://www.ncbi.nlm.nih.gov/pubmed/29661983
http://dx.doi.org/10.18632/aging.101413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940106/
https://www.ncbi.nlm.nih.gov/pubmed/29661983
http://dx.doi.org/10.18632/aging.101413

Ejemplares similares