Rapid Nuclear Exclusion of Hcm1 in Aging Saccharomyces cerevisiae Leads to Vacuolar Alkalization and Replicative Senescence

The yeast, Saccharomyces cerevisiae, like other higher eukaryotes, undergo a finite number of cell divisions before exiting the cell cycle due to the effects of aging. Here, we show that yeast aging begins with the nuclear exclusion of Hcm1 in young cells, resulting in loss of acidic vacuoles. Autop...

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Detalles Bibliográficos
Autores principales: Ghavidel, Ata, Baxi, Kunal, Prusinkiewicz, Martin, Swan, Cynthia, Belak, Zach R., Eskiw, Christopher H., Carvalho, Carlos E., Harkness, Troy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2018
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940150/
https://www.ncbi.nlm.nih.gov/pubmed/29519938
http://dx.doi.org/10.1534/g3.118.200161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940150/
https://www.ncbi.nlm.nih.gov/pubmed/29519938
http://dx.doi.org/10.1534/g3.118.200161

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