Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding

Mesothelin is a cell surface protein that is overexpressed in numerous cancers, including breast, ovarian, lung, liver, and pancreatic tumors. Aberrant expression of mesothelin has been shown to promote tumor progression and metastasis through interaction with established tumor biomarker CA125. Ther...

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Detalles Bibliográficos
Autores principales: Sirois, Allison R., Deny, Daniela A., Baierl, Samantha R., George, Katia S., Moore, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940182/
https://www.ncbi.nlm.nih.gov/pubmed/29738555
http://dx.doi.org/10.1371/journal.pone.0197029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940182/
https://www.ncbi.nlm.nih.gov/pubmed/29738555
http://dx.doi.org/10.1371/journal.pone.0197029

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