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Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid
Dehydroabietic acid (DHAA) is a naturally occurring component of pine resin that was recently shown to open voltage-gated potassium (K(V)) channels. The hydrophobic part of DHAA anchors the compound near the channel’s positively charged voltage sensor in a pocket between the channel and the lipid me...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940250/ https://www.ncbi.nlm.nih.gov/pubmed/29626041 http://dx.doi.org/10.1085/jgp.201711965 |