Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response

Maintenance of genomic integrity is crucial for the preservation of hematopoietic stem cell (HSC) potential. Retrotransposons, spreading in the genome through an RNA intermediate, have been associated with loss of self-renewal, aging, and DNA damage. However, their role in HSCs has not been addresse...

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Detalles Bibliográficos
Autores principales: Barbieri, Daniela, Elvira-Matelot, Emilie, Pelinski, Yanis, Genève, Laetitia, de Laval, Bérengère, Yogarajah, Gayathri, Pecquet, Christian, Constantinescu, Stefan N., Porteu, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940259/
https://www.ncbi.nlm.nih.gov/pubmed/29615469
http://dx.doi.org/10.1084/jem.20170997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940259/
https://www.ncbi.nlm.nih.gov/pubmed/29615469
http://dx.doi.org/10.1084/jem.20170997

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