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Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response
Maintenance of genomic integrity is crucial for the preservation of hematopoietic stem cell (HSC) potential. Retrotransposons, spreading in the genome through an RNA intermediate, have been associated with loss of self-renewal, aging, and DNA damage. However, their role in HSCs has not been addresse...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940259/ https://www.ncbi.nlm.nih.gov/pubmed/29615469 http://dx.doi.org/10.1084/jem.20170997 |