SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-β signaling

Cell cycle quiescence is critical for hematopoietic stem cell (HSC) maintenance. TGF-β signaling in bone marrow niche has been identified in regulating HSC quiescence; however, the intrinsic regulatory mechanisms remain unclear. This study reports that Shp-1 knockout HSCs have attenuated quiescence...

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Detalles Bibliográficos
Autores principales: Jiang, Linjia, Han, Xue, Wang, Jin, Wang, Chen, Sun, Xiaoqiang, Xie, Jiayi, Wu, Guojin, Phan, Hiep, Liu, Zhenguo, Zhang, ChengCheng, Zhao, Meng, Kang, Xunlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940262/
https://www.ncbi.nlm.nih.gov/pubmed/29669741
http://dx.doi.org/10.1084/jem.20171477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940262/
https://www.ncbi.nlm.nih.gov/pubmed/29669741
http://dx.doi.org/10.1084/jem.20171477

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