Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation

Proteasome inhibitors are used as research tools and to treat multiple myeloma, and proteasome activity is diminished in several neurodegenerative diseases. We therefore studied how cells compensate for proteasome inhibition. In 4 h, proteasome inhibitor treatment caused dramatic and selective induc...

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Detalles Bibliográficos
Autores principales: Sha, Zhe, Schnell, Helena M., Ruoff, Kerstin, Goldberg, Alfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940303/
https://www.ncbi.nlm.nih.gov/pubmed/29535191
http://dx.doi.org/10.1083/jcb.201708168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940303/
https://www.ncbi.nlm.nih.gov/pubmed/29535191
http://dx.doi.org/10.1083/jcb.201708168

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