Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization

To relieve endoplasmic reticulum (ER) stress, IRE1 splices XBP1 messenger RNA (mRNA) or engages regulated IRE1-dependent decay (RIDD) of other mRNAs. Upon XBP1 deficiency, IRE1 switches to perform RIDD. We examined IRE1 in XBP1-deficient B cells and discovered that IRE1 undergoes phosphorylation at...

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Detalles Bibliográficos
Autores principales: Tang, Chih-Hang Anthony, Chang, Shiun, Paton, Adrienne W., Paton, James C., Gabrilovich, Dmitry I., Ploegh, Hidde L., Del Valle, Juan R., Hu, Chih-Chi Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940306/
https://www.ncbi.nlm.nih.gov/pubmed/29511123
http://dx.doi.org/10.1083/jcb.201709137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940306/
https://www.ncbi.nlm.nih.gov/pubmed/29511123
http://dx.doi.org/10.1083/jcb.201709137

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