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Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor

Insulin receptor (IR) signaling plays a critical role in the regulation of metabolism and growth in multicellular organisms. IRs are unique among receptor tyrosine kinases in that they exist exclusively as covalent (αβ)(2) homodimers at the cell surface. Transmembrane signaling by the IR can therefo...

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Detalles Bibliográficos
Autores principales: Gutmann, Theresia, Kim, Kelly H., Grzybek, Michal, Walz, Thomas, Coskun, Ünal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940312/
https://www.ncbi.nlm.nih.gov/pubmed/29453311
http://dx.doi.org/10.1083/jcb.201711047