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Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor
Insulin receptor (IR) signaling plays a critical role in the regulation of metabolism and growth in multicellular organisms. IRs are unique among receptor tyrosine kinases in that they exist exclusively as covalent (αβ)(2) homodimers at the cell surface. Transmembrane signaling by the IR can therefo...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940312/ https://www.ncbi.nlm.nih.gov/pubmed/29453311 http://dx.doi.org/10.1083/jcb.201711047 |