Overexpressing TPTE2 (TPIP), a homolog of the human tumor suppressor gene PTEN, rescues the abnormal phenotype of the PTEN(−/−) mutant

One possible approach to normalize mutant cells that are metastatic and tumorigenic, is to upregulate a functionally similar homolog of the mutated gene. Here we have explored this hypothesis by generating an overexpressor of TPTE2 (TPIP), a homolog of PTEN, in PTEN(−/−) mutants, the latter generate...

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Detalles Bibliográficos
Autores principales: Lusche, Daniel F., Buchele, Emma C., Russell, Kanoe B., Soll, Benjamin A., Vitolo, Michele I., Klemme, Michael R., Wessels, Deborah J., Soll, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940379/
https://www.ncbi.nlm.nih.gov/pubmed/29765523
http://dx.doi.org/10.18632/oncotarget.24941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940379/
https://www.ncbi.nlm.nih.gov/pubmed/29765523
http://dx.doi.org/10.18632/oncotarget.24941

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