Selective dissociation between LSD1 and GFI1B by a LSD1 inhibitor NCD38 induces the activation of ERG super-enhancer in erythroleukemia cells

Lysine-specific demethylase 1 (LSD1) is a histone modifier for transcriptional repression involved in the regulation of hematopoiesis. We previously reported that a LSD1 inhibitor NCD38 induces transdifferentiation from erythroid lineage to granulomonocytic lineage and exerts anti-leukemia effect th...

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Detalles Bibliográficos
Autores principales: Yamamoto, Ryusuke, Kawahara, Masahiro, Ito, Shinji, Satoh, Junko, Tatsumi, Goichi, Hishizawa, Masakatsu, Suzuki, Takayoshi, Andoh, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940392/
https://www.ncbi.nlm.nih.gov/pubmed/29765516
http://dx.doi.org/10.18632/oncotarget.24774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940392/
https://www.ncbi.nlm.nih.gov/pubmed/29765516
http://dx.doi.org/10.18632/oncotarget.24774

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