A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells

Misfolding mutations in the DNA-binding domain of p53 alter its conformation, affecting the efficiency with which it binds to chromatin to regulate target gene expression and cell cycle checkpoint functions in many cancers, including glioblastoma. Small molecule drugs that recover misfolded p53 stru...

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Detalles Bibliográficos
Autores principales: Paulmurugan, Ramasamy, Afjei, Rayhaneh, Sekar, Thillai V., Babikir, Husam A., Massoud, Tarik F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940411/
https://www.ncbi.nlm.nih.gov/pubmed/29765555
http://dx.doi.org/10.18632/oncotarget.25138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940411/
https://www.ncbi.nlm.nih.gov/pubmed/29765555
http://dx.doi.org/10.18632/oncotarget.25138

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