Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer

The PI3Kα signaling pathway is frequently hyper-activated in breast cancer (BrCa), as a result of mutations/amplifications in oncogenes (e.g. HER2), decreased function in tumor suppressors (e.g. PTEN) or activating mutations in key components of the pathway. In particular, activating mutations of PI...

Descripción completa

Detalles Bibliográficos
Autores principales: Avivar-Valderas, Alvaro, McEwen, Robert, Taheri-Ghahfarokhi, Amir, Carnevalli, Larissa S., Hardaker, Elizabeth L., Maresca, Marcello, Hudson, Kevin, Harrington, Elizabeth A., Cruzalegui, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940413/
https://www.ncbi.nlm.nih.gov/pubmed/29765551
http://dx.doi.org/10.18632/oncotarget.25118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940413/
https://www.ncbi.nlm.nih.gov/pubmed/29765551
http://dx.doi.org/10.18632/oncotarget.25118

Ejemplares similares