Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation

The p85α protein regulates flux through the PI3K/PTEN signaling pathway, and also controls receptor trafficking via regulation of Rab-family GTPases. In this report, we determined the impact of several cancer patient-derived p85α mutations located within the N-terminal domains of p85α previously sho...

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Detalles Bibliográficos
Autores principales: Mellor, Paul, Marshall, Jeremy D. S., Ruan, Xuan, Whitecross, Dielle E., Ross, Rebecca L., Knowles, Margaret A., Moore, Stanley A., Anderson, Deborah H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940657/
https://www.ncbi.nlm.nih.gov/pubmed/29740032
http://dx.doi.org/10.1038/s41598-018-25487-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940657/
https://www.ncbi.nlm.nih.gov/pubmed/29740032
http://dx.doi.org/10.1038/s41598-018-25487-5

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