Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

RIG-I is a viral RNA sensor that induces the production of type I interferon (IFN) in response to infection with a variety of viruses. Modification of RIG-I with K63-linked poly-ubiquitin chains, synthesised by TRIM25, is crucial for activation of the RIG-I/MAVS signalling pathway. TRIM25 activity i...

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Detalles Bibliográficos
Autores principales: Koliopoulos, Marios G., Lethier, Mathilde, van der Veen, Annemarthe G., Haubrich, Kevin, Hennig, Janosch, Kowalinski, Eva, Stevens, Rebecca V., Martin, Stephen R., Reis e Sousa, Caetano, Cusack, Stephen, Rittinger, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940772/
https://www.ncbi.nlm.nih.gov/pubmed/29739942
http://dx.doi.org/10.1038/s41467-018-04214-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940772/
https://www.ncbi.nlm.nih.gov/pubmed/29739942
http://dx.doi.org/10.1038/s41467-018-04214-8

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