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Synergistic combination of two antimicrobial agents closing each other’s mutant selection windows to prevent antimicrobial resistance

Antimicrobial resistance seriously threatened human health. Combination therapy is generally an effective strategy to fight resistance, while some data on its effects are conflicting. To explore the reasons, the fractional inhibitory concentration indexes (FICIs) of three designed combinations again...

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Detalles Bibliográficos
Autores principales: Xu, Xuejie, Xu, Li, Yuan, Ganjun, Wang, Yimin, Qu, Yunqiu, Zhou, Meijing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940791/
https://www.ncbi.nlm.nih.gov/pubmed/29740150
http://dx.doi.org/10.1038/s41598-018-25714-z