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Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders

During reading acquisition, neural reorganization of the human brain facilitates the integration of letters and speech sounds, which enables successful reading. Neuroimaging and behavioural studies have established that impaired audiovisual integration of letters and speech sounds is a core deficit...

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Autores principales: Karipidis, Iliana I., Pleisch, Georgette, Brandeis, Daniel, Roth, Alexander, Röthlisberger, Martina, Schneebeli, Maya, Walitza, Susanne, Brem, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940897/
https://www.ncbi.nlm.nih.gov/pubmed/29740067
http://dx.doi.org/10.1038/s41598-018-24909-8
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author Karipidis, Iliana I.
Pleisch, Georgette
Brandeis, Daniel
Roth, Alexander
Röthlisberger, Martina
Schneebeli, Maya
Walitza, Susanne
Brem, Silvia
author_facet Karipidis, Iliana I.
Pleisch, Georgette
Brandeis, Daniel
Roth, Alexander
Röthlisberger, Martina
Schneebeli, Maya
Walitza, Susanne
Brem, Silvia
author_sort Karipidis, Iliana I.
collection PubMed
description During reading acquisition, neural reorganization of the human brain facilitates the integration of letters and speech sounds, which enables successful reading. Neuroimaging and behavioural studies have established that impaired audiovisual integration of letters and speech sounds is a core deficit in individuals with developmental dyslexia. This longitudinal study aimed to identify neural and behavioural markers of audiovisual integration that are related to future reading fluency. We simulated the first step of reading acquisition by performing artificial-letter training with prereading children at risk for dyslexia. Multiple logistic regressions revealed that our training provides new precursors of reading fluency at the beginning of reading acquisition. In addition, an event-related potential around 400 ms and functional magnetic resonance imaging activation patterns in the left planum temporale to audiovisual correspondences improved cross-validated prediction of future poor readers. Finally, an exploratory analysis combining simultaneously acquired electroencephalography and hemodynamic data suggested that modulation of temporoparietal brain regions depended on future reading skills. The multimodal approach demonstrates neural adaptations to audiovisual integration in the developing brain that are related to reading outcome. Despite potential limitations arising from the restricted sample size, our results may have promising implications both for identifying poor-reading children and for monitoring early interventions.
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spelling pubmed-59408972018-05-14 Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders Karipidis, Iliana I. Pleisch, Georgette Brandeis, Daniel Roth, Alexander Röthlisberger, Martina Schneebeli, Maya Walitza, Susanne Brem, Silvia Sci Rep Article During reading acquisition, neural reorganization of the human brain facilitates the integration of letters and speech sounds, which enables successful reading. Neuroimaging and behavioural studies have established that impaired audiovisual integration of letters and speech sounds is a core deficit in individuals with developmental dyslexia. This longitudinal study aimed to identify neural and behavioural markers of audiovisual integration that are related to future reading fluency. We simulated the first step of reading acquisition by performing artificial-letter training with prereading children at risk for dyslexia. Multiple logistic regressions revealed that our training provides new precursors of reading fluency at the beginning of reading acquisition. In addition, an event-related potential around 400 ms and functional magnetic resonance imaging activation patterns in the left planum temporale to audiovisual correspondences improved cross-validated prediction of future poor readers. Finally, an exploratory analysis combining simultaneously acquired electroencephalography and hemodynamic data suggested that modulation of temporoparietal brain regions depended on future reading skills. The multimodal approach demonstrates neural adaptations to audiovisual integration in the developing brain that are related to reading outcome. Despite potential limitations arising from the restricted sample size, our results may have promising implications both for identifying poor-reading children and for monitoring early interventions. Nature Publishing Group UK 2018-05-08 /pmc/articles/PMC5940897/ /pubmed/29740067 http://dx.doi.org/10.1038/s41598-018-24909-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Karipidis, Iliana I.
Pleisch, Georgette
Brandeis, Daniel
Roth, Alexander
Röthlisberger, Martina
Schneebeli, Maya
Walitza, Susanne
Brem, Silvia
Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
title Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
title_full Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
title_fullStr Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
title_full_unstemmed Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
title_short Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
title_sort simulating reading acquisition: the link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940897/
https://www.ncbi.nlm.nih.gov/pubmed/29740067
http://dx.doi.org/10.1038/s41598-018-24909-8
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