The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism

The orphan nuclear receptor Nurr1 (also called nuclear receptor-4A2) regulates inflammatory gene expression in glial cells, as well as genes associated with homeostatic and trophic function in dopaminergic neurons. Despite these known functions of Nurr1, an endogenous ligand has not been discovered....

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Detalles Bibliográficos
Autores principales: Hammond, Sean L., Popichak, Katriana A., Li, Xi, Hunt, Lindsay G., Richman, Evan H., Damale, Pranav U., Chong, Edwin K. P., Backos, Donald S., Safe, Stephen, Tjalkens, Ronald B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2018
Materias:
Neuropharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941193/
https://www.ncbi.nlm.nih.gov/pubmed/29626009
http://dx.doi.org/10.1124/jpet.117.246389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941193/
https://www.ncbi.nlm.nih.gov/pubmed/29626009
http://dx.doi.org/10.1124/jpet.117.246389

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