Cargando…

The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism

The orphan nuclear receptor Nurr1 (also called nuclear receptor-4A2) regulates inflammatory gene expression in glial cells, as well as genes associated with homeostatic and trophic function in dopaminergic neurons. Despite these known functions of Nurr1, an endogenous ligand has not been discovered....

Descripción completa

Detalles Bibliográficos
Autores principales:	Hammond, Sean L., Popichak, Katriana A., Li, Xi, Hunt, Lindsay G., Richman, Evan H., Damale, Pranav U., Chong, Edwin K. P., Backos, Donald S., Safe, Stephen, Tjalkens, Ronald B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2018
Materias:	Neuropharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941193/ https://www.ncbi.nlm.nih.gov/pubmed/29626009 http://dx.doi.org/10.1124/jpet.117.246389

Ejemplares similares

Compensatory Expression of Nur77 and Nurr1 Regulates NF-κB–Dependent Inflammatory Signaling in Astrocytes
por: Popichak, Katriana A., et al.
Publicado: (2018)

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis
por: Svensson, Kjell A., et al.
Publicado: (2017)

Adenylyl Cyclase 1 Is Required for Ethanol-Induced Locomotor Sensitization and Associated Increases in NMDA Receptor Phosphorylation and Function in the Dorsal Medial Striatum
por: Bosse, Kelly E., et al.
Publicado: (2017)

Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese
por: Popichak, Katriana A., et al.
Publicado: (2018)

Chemoprevention of Skin Cancer with 1,1-Bis (3′-Indolyl)-1-(Aromatic) Methane Analog through Induction of the Orphan Nuclear Receptor, NR4A2 (Nurr1)
por: Boakye, Cedar H. A., et al.
Publicado: (2013)

Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro
por: Greenhill, S.D., et al.
Publicado: (2010)

Strain differences in proliferation of progenitor cells in the dentate gyrus of the adult rat and the response to fluoxetine are dependent on corticosterone
por: AlAhmed, S., et al.
Publicado: (2008)

Limbic system associated membrane protein as a potential target for neuropsychiatric disorders
por: Innos, Jürgen, et al.
Publicado: (2013)

Ethanol Tolerance Affects Endogenous Adenosine Signaling in Mouse Hippocampus
por: Zhang, Dali, et al.
Publicado: (2016)

Task- and Treatment Length–Dependent Effects of Vortioxetine on Scopolamine-Induced Cognitive Dysfunction and Hippocampal Extracellular Acetylcholine in Rats
por: Pehrson, Alan L., et al.
Publicado: (2016)

Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606
por: Wagner, Steven L., et al.
Publicado: (2017)

Noncompetitive Inhibition of 5-HT(3) Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling
por: Jarvis, Gavin E., et al.
Publicado: (2016)

Meet Our Editorial Board Member
por: Fiore, M.
Publicado: (2020)

The Kinetic Component in Drug Discovery: Using the Most Basic Pharmacological Concepts to Advance in Selecting Drugs to Combat CNS Diseases
por: Franco, Rafael, et al.
Publicado: (2020)

An Overview of the Heterogeneity of Major Depressive Disorder: Current Knowledge and Future Prospective
por: Athira, Kaipuzha Venu, et al.
Publicado: (2020)

A Mechanistic Rationale for PDE-4 Inhibitors to Treat Residual Cognitive Deficits in Acquired Brain Injury
por: Schreiber, Rudy, et al.
Publicado: (2020)

Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation
por: Bagdas, Deniz, et al.
Publicado: (2020)

Animal Galectins and Plant Lectins as Tools for Studies in Neurosciences
por: Araújo, João Ronielly Campêlo, et al.
Publicado: (2020)

The Contribution of Formyl Peptide Receptor Dysfunction to the Course of Neuroinflammation: A Potential Role in the Brain Pathology
por: Trojan, Ewa, et al.
Publicado: (2020)

Vasopressin & Oxytocin in Control of the Cardiovascular System: An Updated Review
por: Japundžić-Žigon, Nina, et al.
Publicado: (2020)

Meet Our Editorial Board Member
por: Boehm, S.
Publicado: (2020)

The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum
por: Boccella, Serena, et al.
Publicado: (2020)

Pharmacological Interventions and Rehabilitation Approach for Enhancing Brain Self-repair and Stroke Recovery
por: Szelenberger, Rafał, et al.
Publicado: (2020)

Nimodipine Reappraised: An Old Drug with a Future
por: Carlson, Andrew P., et al.
Publicado: (2020)

Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling
por: Liu, Yan, et al.
Publicado: (2020)

Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone
por: Zhang, Leilei, et al.
Publicado: (2020)

Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice
por: Inyang, Kufreobong E., et al.
Publicado: (2019)

Age- and Sex-Specific Plasticity in Dopamine Transporter Function Revealed by Food Restriction and Exercise in a Rat Activity-Based Anorexia Paradigm
por: Gilman, T. Lee, et al.
Publicado: (2019)

Protection from Amyloid β Peptide–Induced Memory, Biochemical, and Morphological Deficits by a Phosphodiesterase-4D Allosteric Inhibitor
por: Cui, Su-Ying, et al.
Publicado: (2019)

Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal N-Methyl-d-Aspartate Receptors, Long-Term Potentiation, and Learning
por: Izumi, Yukitoshi, et al.
Publicado: (2021)

Levetiracetam Pharmacokinetics and Brain Uptake in a Lateral Fluid Percussion Injury Rat Model
por: Coles, Lisa D., et al.
Publicado: (2023)

Social isolation induces schizophrenia-like behavior potentially associated with HINT1, NMDA receptor 1, and dopamine receptor 2
por: Li, Bai-Jia, et al.
Publicado: (2017)

Friedel–Crafts Reaction of Acylsilanes: Highly Chemoselective Synthesis of 1-Hydroxy-bis(indolyl)methanes and 1-Silyl-bis(indolyl)methanes Derivatives
por: Li, Qi, et al.
Publicado: (2023)

1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice
por: Su, Yunpeng, et al.
Publicado: (2007)

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer
por: Vanderlaag, Kathy, et al.
Publicado: (2010)

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity
por: Kirkley, Kelly S., et al.
Publicado: (2017)

Ukgansan Protects Dopaminergic Neurons against MPTP-Induced Neurotoxicity via the Nurr1 Signaling Pathway
por: Chae, In-Cheol, et al.
Publicado: (2022)

The influence of μ-opioid and noradrenaline reuptake inhibition in the modulation of pain responsive neurones in the central amygdala by tapentadol in rats with neuropathy
por: Gonçalves, Leonor, et al.
Publicado: (2015)

Modeling Neuronal Diseases in Zebrafish in the Era of CRISPR
por: Espino-Saldaña, Angeles Edith, et al.
Publicado: (2020)

Trigeminal Neuralgia: Basic and Clinical Aspects
por: Araya, Erika Ivanna, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_a5vk42fo8svrmpav04cv7thlu3