Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

BACKGROUND: Currently, there are no available targeted therapy options for non-V600 BRAF mutated tumors. The aim of this study was to investigate the effects of RAF and MEK concurrent inhibition on tumor growth, migration, signaling and apoptosis induction in preclinical models of non-V600 BRAF muta...

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Detalles Bibliográficos
Autores principales: Molnár, Eszter, Rittler, Dominika, Baranyi, Marcell, Grusch, Michael, Berger, Walter, Döme, Balázs, Tóvári, József, Aigner, Clemens, Tímár, József, Garay, Tamás, Hegedűs, Balázs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941622/
https://www.ncbi.nlm.nih.gov/pubmed/29739364
http://dx.doi.org/10.1186/s12885-018-4455-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941622/
https://www.ncbi.nlm.nih.gov/pubmed/29739364
http://dx.doi.org/10.1186/s12885-018-4455-x

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