Evaluating Hepatobiliary Transport with (18)F-Labeled Bile Acids: The Effect of Radiolabel Position and Bile Acid Structure on Radiosynthesis and In Vitro and In Vivo Performance

INTRODUCTION: An in vivo determination of bile acid hepatobiliary transport efficiency can be of use in liver disease and preclinical drug development. Given the increased interest in bile acid Positron Emission Tomography- (PET-) imaging, a further understanding of the impact of 18-fluorine substit...

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Detalles Bibliográficos
Autores principales: De Lombaerde, Stef, Kersemans, Ken, Neyt, Sara, Verhoeven, Jeroen, Vanhove, Christian, De Vos, Filip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941726/
https://www.ncbi.nlm.nih.gov/pubmed/29853807
http://dx.doi.org/10.1155/2018/6345412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941726/
https://www.ncbi.nlm.nih.gov/pubmed/29853807
http://dx.doi.org/10.1155/2018/6345412

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