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Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent

5-Methoxyindole-2-carboxylic acid (MICA) is a potent hypoglycemic agent that inhibits gluconeogenesis in the liver. It is also a well-known inhibitor of mitochondrial dihydrolipoamide dehydrogenase. MICA was extensively studied in the 1960s and 1970s and was once tested for its antidiabetic effect i...

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Autor principal: Yan, Liang-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942165/
https://www.ncbi.nlm.nih.gov/pubmed/29765243
http://dx.doi.org/10.2147/DMSO.S166485
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author Yan, Liang-Jun
author_facet Yan, Liang-Jun
author_sort Yan, Liang-Jun
collection PubMed
description 5-Methoxyindole-2-carboxylic acid (MICA) is a potent hypoglycemic agent that inhibits gluconeogenesis in the liver. It is also a well-known inhibitor of mitochondrial dihydrolipoamide dehydrogenase. MICA was extensively studied in the 1960s and 1970s and was once tested for its antidiabetic effect in diabetic Chinese hamsters, whereby MICA was shown to exhibit pronounced glucose-lowering ability while also leading to increased rate of death of the diabetic animals. Since then, MICA’s potential ability in lowering blood glucose in diabetes has never been revisited. In my opinion, MICA should be comprehensively reexplored for its antidiabetic properties in a variety of rodent diabetes models. For a given animal model, its dose-dependent effect and the effects of different routes of administrations as well as its synergistic effects with other glucose-lowering drugs should also be investigated. More studies in the future on this chemical may provide novel insights into its role as an antidiabetic agent.
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spelling pubmed-59421652018-05-14 Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent Yan, Liang-Jun Diabetes Metab Syndr Obes Perspectives 5-Methoxyindole-2-carboxylic acid (MICA) is a potent hypoglycemic agent that inhibits gluconeogenesis in the liver. It is also a well-known inhibitor of mitochondrial dihydrolipoamide dehydrogenase. MICA was extensively studied in the 1960s and 1970s and was once tested for its antidiabetic effect in diabetic Chinese hamsters, whereby MICA was shown to exhibit pronounced glucose-lowering ability while also leading to increased rate of death of the diabetic animals. Since then, MICA’s potential ability in lowering blood glucose in diabetes has never been revisited. In my opinion, MICA should be comprehensively reexplored for its antidiabetic properties in a variety of rodent diabetes models. For a given animal model, its dose-dependent effect and the effects of different routes of administrations as well as its synergistic effects with other glucose-lowering drugs should also be investigated. More studies in the future on this chemical may provide novel insights into its role as an antidiabetic agent. Dove Medical Press 2018-05-04 /pmc/articles/PMC5942165/ /pubmed/29765243 http://dx.doi.org/10.2147/DMSO.S166485 Text en © 2018 Yan. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Perspectives
Yan, Liang-Jun
Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
title Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
title_full Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
title_fullStr Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
title_full_unstemmed Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
title_short Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
title_sort reexploring 5-methoxyindole-2-carboxylic acid (mica) as a potential antidiabetic agent
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942165/
https://www.ncbi.nlm.nih.gov/pubmed/29765243
http://dx.doi.org/10.2147/DMSO.S166485
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