A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells

[Image: see text] Sickle cell disease is an inherited disorder of hemoglobin (Hb). During a sickle cell crisis, deoxygenated sickle hemoglobin (deoxyHbS) polymerizes to form fibers in red blood cells (RBCs), causing the cells to adopt “sickled” shapes. Using small molecules to increase the affinity...

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Detalles Bibliográficos
Autores principales: Nakagawa, Akito, Ferrari, Michele, Schleifer, Grigorij, Cooper, Marissa K., Liu, Chen, Yu, Binglan, Berra, Lorenzo, Klings, Elizabeth S., Safo, Ronni S., Chen, Qiukan, Musayev, Faik N., Safo, Martin K., Abdulmalik, Osheiza, Bloch, Donald B., Zapol, Warren M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942180/
https://www.ncbi.nlm.nih.gov/pubmed/29634905
http://dx.doi.org/10.1021/acs.molpharmaceut.8b00108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942180/
https://www.ncbi.nlm.nih.gov/pubmed/29634905
http://dx.doi.org/10.1021/acs.molpharmaceut.8b00108

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