Mapping Interactions with the Chaperone Network Reveals Factors that Protect Against Tau Aggregation

A network of molecular chaperones is known to bind proteins (“clients”) and balance their folding, function and turnover. However, it is often not clear which chaperones are critical for selective recognition of individual clients. It is also not clear why these key chaperones might fail in protein...

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Detalles Bibliográficos
Autores principales: Mok, Sue-Ann, Condello, Carlo, Freilich, Rebecca, Gillies, Anne, Arhar, Taylor, Oroz, Javier, Kadavath, Harindranath, Julien, Olivier, Assimon, Victoria A., Rauch, Jennifer N., Dunyak, Bryan M., Lee, Jungsoon, Tsai, Francis T.F., Wilson, Mark R., Zweckstetter, Markus, Dickey, Chad A., Gestwicki, Jason E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942583/
https://www.ncbi.nlm.nih.gov/pubmed/29728653
http://dx.doi.org/10.1038/s41594-018-0057-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942583/
https://www.ncbi.nlm.nih.gov/pubmed/29728653
http://dx.doi.org/10.1038/s41594-018-0057-1

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