High Performance Virtual Screening by Targeting a High-resolution RNA Dynamic Ensemble

Dynamic ensembles hold great promise in advancing RNA-targeted drug discovery. Here, we subjected the transactivation response element (TAR) RNA from human immunodeficiency virus type-1 to experimental high-throughput screening against ~100,000 drug-like small molecules. Results were augmented with...

Descripción completa

Detalles Bibliográficos
Autores principales: Ganser, Laura R., Lee, Janghyun, Rangadurai, Atul, Merriman, Dawn K., Kelly, Megan L., Kansal, Aman D., Sathyamoorthy, Bharathwaj, Al-Hashimi, Hashim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942591/
https://www.ncbi.nlm.nih.gov/pubmed/29728655
http://dx.doi.org/10.1038/s41594-018-0062-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942591/
https://www.ncbi.nlm.nih.gov/pubmed/29728655
http://dx.doi.org/10.1038/s41594-018-0062-4

Ejemplares similares