Identification of a peptide inhibitor for the histone methyltransferase WHSC1

WHSC1 is a histone methyltransferase that is responsible for mono- and dimethylation of lysine 36 on histone H3 and has been implicated as a driver in a variety of hematological and solid tumors. Currently, there is a complete lack of validated chemical matter for this important drug discovery targe...

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Detalles Bibliográficos
Autores principales: Morrison, Michael J., Boriack-Sjodin, P. Ann, Swinger, Kerren K., Wigle, Tim J., Sadalge, Dipti, Kuntz, Kevin W., Scott, Margaret Porter, Janzen, William P., Chesworth, Richard, Duncan, Kenneth W., Harvey, Darren M., Lampe, John W., Mitchell, Lorna H., Copeland, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942779/
https://www.ncbi.nlm.nih.gov/pubmed/29742153
http://dx.doi.org/10.1371/journal.pone.0197082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942779/
https://www.ncbi.nlm.nih.gov/pubmed/29742153
http://dx.doi.org/10.1371/journal.pone.0197082

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