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Characterization of SNF472 pharmacokinetics and efficacy in uremic and non-uremic rats models of cardiovascular calcification

End-stage renal disease is strongly associated with progressive cardiovascular calcification (CVC) and there is currently no therapy targeted to treat CVC. SNF472 is an experimental formulation under development for treatment of soft tissue calcification. We have investigated the pharmacokinetics of...

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Detalles Bibliográficos
Autores principales: Ferrer, Miguel D., Ketteler, Markus, Tur, Fernando, Tur, Eva, Isern, Bernat, Salcedo, Carolina, Joubert, Pieter H., Behets, Geert J., Neven, Ellen, D’Haese, Patrick C., Perelló, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942814/
https://www.ncbi.nlm.nih.gov/pubmed/29742152
http://dx.doi.org/10.1371/journal.pone.0197061