Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

Genome-wide association studies (GWAS) have identified over 100 risk loci for schizophrenia, but the causal mechanisms remain largely unknown. We performed a transcriptome-wide association study (TWAS) integrating a schizophrenia GWAS of 79,845 individuals from the Psychiatric Genomics Consortium wi...

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Detalles Bibliográficos
Autores principales: Gusev, Alexander, Mancuso, Nicholas, Won, Hyejung, Kousi, Maria, Finucane, Hilary K., Reshef, Yakir, Song, Lingyun, Safi, Alexias, McCarroll, Steven, Neale, Benjamin, Ophoff, Roel A., O’Donovan, Michael C, Crawford, Gregory E., Geschwind, Daniel H., Katsanis, Nicholas, Sullivan, Patrick F., Pasaniuc, Bogdan, Price, Alkes L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942893/
https://www.ncbi.nlm.nih.gov/pubmed/29632383
http://dx.doi.org/10.1038/s41588-018-0092-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942893/
https://www.ncbi.nlm.nih.gov/pubmed/29632383
http://dx.doi.org/10.1038/s41588-018-0092-1

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