Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells

We report that Histone Deacetylase 7 (HDAC7) controls the thymic effector programming of Natural Killer T (NKT) cells, and that interference with this function contributes to tissue-specific autoimmunity. Gain of HDAC7 function in thymocytes blocks both negative selection and NKT development, and di...

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Detalles Bibliográficos
Autores principales: Kasler, Herbert G, Lee, Intelly S, Lim, Hyung W, Verdin, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943034/
https://www.ncbi.nlm.nih.gov/pubmed/29664401
http://dx.doi.org/10.7554/eLife.32109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943034/
https://www.ncbi.nlm.nih.gov/pubmed/29664401
http://dx.doi.org/10.7554/eLife.32109

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