Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs

The receptor tyrosine kinase, erythropoietin-producing hepatocellular A4 (EphA4), was recently identified as a molecular target for Alzheimer’s disease (AD). We found that blockade of the interaction of the receptor and its ligands, ephrins, alleviates the disease phenotype in an AD transgenic mouse...

Descripción completa

Detalles Bibliográficos
Autores principales: Gu, Shuo, Fu, Wing-Yu, Fu, Amy K. Y., Tong, Estella Pui Sze, Ip, Fanny C. F., Huang, Xuhui, Ip, Nancy Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943255/
https://www.ncbi.nlm.nih.gov/pubmed/29743517
http://dx.doi.org/10.1038/s41598-018-25790-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943255/
https://www.ncbi.nlm.nih.gov/pubmed/29743517
http://dx.doi.org/10.1038/s41598-018-25790-1

Ejemplares similares